Pharmaceutical suspension:
Pharmaceutical suspension is biphasic,
heterogeneous system in which solid particles are suspended uniformly
throughout the solvent is called suspension.
Solid particles:
Suspended solid / internal phase / discontinuous
phase / API (therapeutic agent) / dispersed phase
Solvent:
Suspended medium / dispersion medium /
external phase / continuous phase
They are insoluble in solvent that is
why suspended in nature.
Reason for suspension dosage form:
- Insoluble solid particles (API)
- To mask the bitter taste of drug
- To enhance the rate of absorption of drug (applied to all dosage form)
- To control / sustained the release of drug
- More stable dosage form
Properties of suspension:
- It should be easily redispersed
- No formation of hard cake
- It should be physically and chemically stable
- Free from gretty properties
Classification of suspension:
1-based on route of administration
A) Oral suspension
B) Topical suspension
C) Parenteral suspension
A) Oral suspension:
For example
- Tetracycline
- Paracetamol
- Antacid
B) Topical suspension:
For example
- Calcium lotion
C)parenteral suspension:
For example
- Procain
- Pencillin G suspension
- Insulin zinc suspension
2-Based on concentration of solid particles:
A) 2-10% W/V suspension
B) 50% W/V suspension
A) 2-10% W/V suspension:
Diluent suspension
For example
- Steroids
- Prednesolone acetate
- Cortisone acetate
B)50% W/V suspension:
Concentrated suspension
For example
- zinc oxide suspension
3-based on size of solid particles:
A) Colloidal suspension
B) Coarse suspension
A) Colloidal suspension:
In colloidal suspension particle size
should be less than 1 micron meter.
B) Coarse suspension:
In coarse suspension particles size
should be more than 1 micron meter.
4-based on behaviour of dispersed phase
A) Flocculated suspension
B) Deflocculated suspension
Difference between flocculated and deflocculated suspension:
Flocculated suspension:
- In flocculated suspension there is the formation of flocks of dispersed phase in dispersion medium.
What is flocks?
Flocks is lose aggregates or network
of particles and they are porous in nature.
- Flocculated suspension are pharmaceutically more stable form they are easily re dispersed.
- In flocculated suspension rate of sedimentation is fast.
- In flocculated suspension sediment is rapidly form and loosely packed that’s why no formation of hard cake.
- The flocculated suspension use for long term.
- Flock stick to the side of container.
When flocks settle down we get cleared
supernated liquid.
- In flocculated suspension We add flocculating agent.
Deflocculated suspension:
In deflocculated the individual
particle dispersed in dispersion medium.
- In deflocculated suspension rate of sedimentation is slow.
- In deflocculated suspension sediment is closely packed and form a hard cake.
- Deflocculated suspension is good for short period of time not useful for long period.
- In deflocculated suspension individual particles do not stick to the walls of container.
- Large size particles settle down and small size particles remain dispersed so there will be no supernated liquid.
- In deflocculated suspension we add deflocculating agent.
Learn more
Searching Tags
What is pharmaceutical suspension?
What is solid particles in suspension?
What is solvent in suspension?
Reason for suspension dosage form
5 reasons for making suspension
Properties of suspension
4 important properties of suspension
Classification of suspension
Classification based on route of
administration
Examples of oral suspension
Examples of topical suspension
Examples of parenteral suspension
Classification based on concentration
of solid
What is 2-10% W/V suspension?
What is 50% W/V suspension?
Classification based on size of solid
particles
What is colloids suspension?
What is coarse suspension?
Classification based on behaviour of
dispersed phase
What is flocculated suspension?
What is deflocculated suspension?
Differences between flocculated suspension and deflocculated suspension
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