Classification Of Mixing

Mixing:

•pharmaceutical technology process which is used to mix two or more than two ingredients to form a homogeneous mixture further used to form a dosage form.

•to put together different ingredients in one mass or one system.

•Mixing is the process in which two or more than two ingredients in mixed or roughly mixed that are heated in such a manner that each particle of one ingredient lies as nearly as possible to the particle of other ingredient.

•Mixing is a unit operation process that result in randomization of dissimilar particles in one system.

Importance of Mixing:

1)To obtain the homogeneous mixture ( physical mixture).

2)mixing is used to improve the appearance of mixture.

3)mixing is used to improve the texture of mixture.

4)mixing is used to provide the smooth texture.

5)mixing is used to initiate the physical and chemical reactions.

Physical reactions such as dissolution and chemical reactions such as precipitation.

E.g. when the solid like sugar is put in the solvent like water and they are mixed properly then this is dissolution the solution in one phase.

6)mixing is used to facilitate heat transfer from high to low.

E.g. there is hot water and cold water when we mix them together the heat from the hot water is transfer towards the cold water and we get mixture that is warm water.

7)mixing is used even for the distribution of colours.

E.g. in the coloured tablets . If there is no proper mixing the tablet become improper coloured so there is unequal distribution of colours like one part is dim coloured and the other part is high coloured.

8)mixing is used to facilitate uniformity of composition of mixed ingredients.  Every ingredient in the tablet should be equally mixed.

9)mixing is used to provide correct dose of active pharmaceutical ingredients.

If non uniform of composition then there is no proper correct dose.

10)mixing is used for the mixing of lubricants in granules.

Classification of Mixing:

Mixing is classified into 4 categories

1)liquid liquid mixing

2)liquid solid mixing

3)solid solid mixing

4)semi solid mixing

1)liquid liquid Mixing:

•mixing of immiscible liquids

E.g. mixing of water and milk (emulsion)

•mixing of miscible liquids

E.g. mixing of water and alcohol (solution)

2)liquid solid mixing:

•mixing of liquid and soluble solid

E.g. mixing of sugar and water (solution) homogeneous mixing.

•mixing of liquid and insoluble solid

E.g. mixing of sand in water (suspension) heterogeneous mixing

3)solid solid mixing:

Solid solid mixing include powder mixing / dry mixing

E.g. tablets,  capsules

4)semi solid mixing:

Semi solid mixing include semi solid base or solid and liquid.

E.g. ointments,  pastes, creams

 

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